After finishing high school, Daniel Vijlbrief (1975) studied at Millersville University of Pennsylvania through the Fulbright scholarship program. Returning to the Netherlands, he studied Medicine at Utrecht University. He specialized in Pediatrics in Utrecht and Tilburg. He continued in Neonatology in the Wilhelmina children’s hospital in Utrecht and the Isala Clinics in Zwolle. He works as a consultant neonatologist in Utrecht. In 2015, he finished his Ph.D. in Medicine with the title ‘Cardiac Biomarkers in Neonatology’. He is currently investigating the possibilities of Big Data in neonatal medicine, the Big Data for Small Babies (BD4SB) project. This project aims to build an early warning system and decision support tool for late-onset neonatal sepsis. Furthermore, investigations are on the way to apply Deep learning to retinopathy of prematurity. Future research will be directed toward bringing algorithms to clinical care in newborn medicine to improve the outcome of infants in the NICU smartly.