Matthijs Jore

Department of Medical Microbiology Radboudumc, Nijmegen

After completing an MSc in Molecular Sciences (WUR, NL), he did his PhD in the group of Prof. dr. John van der Oost (WUR, NL) where he studied the CRISPR-Cas system in bacteria, which was just discovered at that time. Thereafter, as a postdoc at Oxford University, he investigated how proteins in tick spit inhibit the human complement system. Using protein crystallography, he demonstrated how these proteins bind to human complement proteins, which also led to new insights into complement activation. Since 2016, he has been working as a researcher within the malaria research group at Radboud university medical center. He leads a research team working on the preclinical development of transmission blocking vaccines and antibodies. This includes the discovery and in vitro and in vivo validation of new vaccine candidates and human antibodies. He also contributes to the development of a vaccine and therapeutic antibody that are currently in healthy volunteers. In 2019 he received a VIDI grant from NWO to investigate how malaria parasites can escape the human complement system and how the complement system can be used to make more effective malaria vaccines.